Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives

Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives

Inhibition of repair-related DNA polymerases by vitamin Ks, their related quinone derivatives and associated inflammatory activity (Review).

Vitamin Ks (VKs) are fat-soluble quinone compounds known to have various bioactivities. This review describes the inflammatory effects of VKs and their related quinone derivatives based on DNA polymerase (pol) inhibition. VK3, but not VK1 or VK2 (=MK-4), inhibited the activity of human pol γ, which is the DNA replicative pol in mitochondria. Of th...

DNA polymerase λ - a novel DNA repair enzyme in higher plant genome

DNA polymerase lambda (Pol λ) is a novel family X DNA polymerase which has been shown to play key role in nuclear DNA repair and meiotic recombination. Recent studies in mammals support function of this enzyme in base excision repair in response to oxidative DNA damage. However, in plants the biological function of Pol λ in oxidative stress response is still largely unknown. This review will su...

Structure–Function Studies of DNA Polymerase λ

DNA polymerase λ (pol λ) functions in DNA repair with its main roles considered to be filling short gaps during repair of double-strand breaks by nonhomologous end joining and during base excision repair. As indicated by structural and biochemical studies over the past 10 years, pol λ shares many common properties with other family X siblings (pol β, pol μ, and terminal deoxynucleotidyl transfe...

DNA pol λ's extraordinary ability to stabilize misaligned DNA.

DNA polymerases have the venerable task of maintaining genome stability during DNA replication and repair. Errors, nonetheless, occur with error propensities that are polymerase specific. For example, DNA polymerase λ (pol λ) generates single-base deletions through template-strand slippage within short repetitive DNA regions much more readily than does the closely related polymerase β (pol β). ...